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Article

IL-4 regulates skin homeostasis and the predisposition toward allergic skin inflammation.

Journal of immunology (Baltimore, Md. : 1950) - 15 Mar 2010

Sehra Sarita, Yao Yongxue, Howell Michael D, Nguyen Evelyn T, Kansas Geoffrey S, Leung Donald Y M, Travers Jeffrey B, Kaplan Mark H

Abstract excerpt

IL-4 promotes the development of Th2 cells and allergic inflammation. In atopic dermatitis lesions, IL-4 decreases the expression of multiple genes associated with innate defense, including genes in the epidermal differentiation complex (EDC) that regulate epidermal barrier function. However, it is not clear whether IL-4 also contributes to homeostatic control of EDC genes. In this report, we demonstrate that...

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Identifiers

PMID: 20147633
DOI: 10.4049/jimmunol.0901860
PMCID: PMC2837507

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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