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Article

STAT6 gain-of-function variant exacerbates multiple allergic symptoms

17 Dec 2022

Abstract excerpt

Background Allergic diseases were long considered to be complex multifactorial disorders. However, recent findings indicate that severe allergic inflammation can be caused by monogenic immune defects. Objectives We sought to clarify the molecular pathogenesis of a patient with early-onset multiple allergic diseases, a high serum IgE level, hypereosinophilia, treatment-resistant severe atopic dermatitis with...

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PMID: 36538978
DOI: 10.1016/j.jaci.2022.12.802

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