Article

A Pseudotime-Dependent TWAS Framework Identifies Disease Genes along Cell Developmental Paths

2025-10-29

Abstract excerpt

Transcriptome-wide association studies (TWAS) link genes to disease risk by integrating gene expression with genome-wide association study (GWAS) data, where the use of bulk-tissue expression data typically provides gene-disease association interpretations at tissue levels. Recently, the increasing availability of single-cell gene expression profiles provides an opportunity to to dissect these associations at fine...

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Literature Corpus work: cdd5ca8b-cf9d-515c-847e-4da6c7c10b11
DOI: 10.1101/2025.10.28.25338929

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