Article

Uncovering Pseudotime-Varying Genetic Causal Effects Along Single-Cell Trajectories for Pulmonary Disease Trait

2026-06-10

Abstract excerpt

With the increasing accessibility of single-cell RNA sequencing (scRNA-seq) data, cell-type-specific gene expression can be linked to complex traits through pseudo-bulk method, which considered aggregated gene expression from multiple cells of the same annotated cell type per individual and clearly shows the limitation of ignoring intra-individual cell-to-cell variability. Concurrently, pseudotime trajectory infer...

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Literature Corpus work: d6b18c29-98b5-59f1-bc0b-220a4f5d0722
DOI: 10.64898/2026.06.08.730759

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