Article

A novel HLA Class II presentation prediction algorithm deciphers immunogenic CD4 epitopes specific to KRAS G12C

2024-12-10

Abstract excerpt

Accurate prediction of peptide presentation by HLA molecules is important for generation of effective individualized cancer vaccines and immunotherapies. While presentation prediction algorithms for HLA class I have been successfully applied in the context of such therapies, improved prediction algorithms for class II are needed. EDGE-II is a novel algorithm based on a protein large language model that has a learn...

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Literature Corpus work: e6b0eccc-9d23-5a26-8258-4cfa7988a7ba
DOI: 10.1101/2024.12.06.627073

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