Article

Precision neoantigen discovery using large-scale immunopeptidomes and composite modeling of MHC peptide presentation

2021-05-01

Abstract excerpt

Major histocompatibility complex (MHC)-bound peptides that originate from tumor-specific genetic alterations, known as neoantigens, are an important class of anti-cancer therapeutic targets. Accurately predicting peptide presentation by MHC complexes is a key aspect of discovering therapeutically relevant neoantigens. Technological improvements in mass-spectrometry-based immunopeptidomics and advanced modeling tec...

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Literature Corpus work: 70624a50-9feb-5f9d-b6e4-c879d336de6c
DOI: 10.1101/2021.04.30.442203

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