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Article

CapHLA: a comprehensive tool to predict peptide presentation and binding to HLA class I and class II

22 Nov 2024

Abstract excerpt

Human leukocyte antigen class I (HLA-I) and class II (HLA-II) proteins play an essential role in epitope binding and presentation to initiate an immune response. Accurate prediction of peptide-HLA (pHLA) binding and presentation is critical for developing effective immunotherapies. However, current tools can predict antigens exclusively for pHLA-I or pHLA-II, but not both; have constraints on peptide length; and...

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PMID: 39688477
DOI: 10.1093/bib/bbae595

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