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Article

AI-driven neoantigen identification: a comprehensive review from somatic variant calling to T cell recognition.

Journal of translational medicine - 6 Jul 2026

Bakhshian Atefeh, Ghorghanlu Sajjad, Atanaki Fereshteh Fallah, Ezadyar Elham Erfani, Ashkiyan Azadeh, Etemadi Ali, Negahdari Babak, Kavousi Kaveh, Kardar Gholamali, Mazloomi Mohammadali

Abstract excerpt

BACKGROUND: Neoantigens-tumor-specific peptides generated by somatic mutations-are central targets of effective anticancer T cell immunity and underpin the clinical success of immune checkpoint blockade and personalized cancer vaccines. Advances in high-throughput sequencing, immunopeptidomics, and artificial intelligence (AI) have transformed neoantigen discovery from tailored experimental workflows into...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42410432
DOI: 10.1186/s12967-026-08535-x
PMCID: PMC13378337

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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