Article

Transcriptional Readthrough at <i>Atf4</i> Locus Suppresses <i>Rps19bp1</i> and Impairs Heart Development

2025-08-29

Abstract excerpt

<h4>BACKGROUND</h4> Activating Transcription Factor 4 (ATF4) functions as a transcriptional regulator in various cell types and tissues under both physiological and pathological conditions. While previous studies have linked ATF4 activation with promoting cardiomyocyte (CM) death in dilated cardiomyopathy (DCM), atrial fibrillation, and heart failure, its role in developing CMs remains unexplored. <h4>METHODS</h4...

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Literature Corpus work: e6a5efe7-bde8-5f79-9cf3-60fd09393bb1
DOI: 10.1101/2025.08.26.672495

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