Article

MYBPC3 deficiency in cardiac fibroblasts drives their activation and contributes to fibrosis

2022-07-05

Abstract excerpt

<title>Abstract</title> <p>Genetic mutations in the <italic>MYBPC3</italic> gene encoding cardiac myosin binding protein C (cMyBP-C) are the most common cause of hypertrophic cardiomyopathy (HCM). Myocardial fibrosis (MF) plays a critical role in the development of HCM. However, the mechanism for mutant <italic>MYBPC3</italic>-induced MF is not well defined. In this study, we developed a R495Q mutant pig model us...

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Literature Corpus work: 9d17ec09-26cc-56d7-a741-aa69deba3784
DOI: 10.21203/rs.3.rs-1724020/v1

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