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Article

Transcriptional readthrough at Atf4 locus suppresses Rps19bp1 and impairs heart development.

Cardiovascular research - 14 Feb 2026

Zhang Zengming, Wu Tongbin, Chen Zeyu, Chen Danni, Liang Zhengyu, Adams Christopher, Gu Yusu, Ye Mao, Barroga Fhujjen, Evans Sylvia, Zhou Xiaohai, Chen Ju

Abstract excerpt

AIMS: Activating transcription factor 4 (ATF4) functions as a transcriptional regulator in various cell types and tissues under both physiological and pathological conditions. While previous studies have linked ATF4 activation with promoting cardiomyocyte (CM) death in dilated cardiomyopathy (DCM), atrial fibrillation, and heart failure, its role in developing CMs remains unexplored. METHODS AND RESULTS: We...

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Topics

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Share to Activating Transcription Factor 4
Share to Gene Expression Regulation, Developmental

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mice, Knockout

Share to Myocytes, Cardiac

Share to Ribosomal Proteins

Share to Transcription, Genetic

Share to Tumor Suppressor Protein p53

Source

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Identifiers

PMID: 41248983
DOI: 10.1093/cvr/cvaf237
PMCID: PMC13012809

Genes

ATF4
RPS19BP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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