Article

Polycystin-1 C-Terminus Regulates Protein Synthesis-Related Pathways in Cardiomyocytes

2026-03-24

Abstract excerpt

<h4>ABSTRACT</h4> Pathologic cardiac hypertrophy requires increased protein synthesis, but the mechanosensors that link membrane stretch to translational control remain poorly understood. Polycystin-1 (PC1), encoded by PKD1 , has been proposed as a cardiac mechanosensor, with its C-terminal tail (PC1-CT) promoting hypertrophy in rodent cardiomyocytes. However, its subcellular localization and downstream signalin...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7bb8f326-bc5f-5531-96c2-5f20014ccc54
DOI: 10.64898/2026.03.21.713243

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Polycystin-1 C-Terminus Regulates Protein Synthesis-Related Pathways in CardiomyocytesDOI 10.64898/2026.03.21.713243Read

Muscle specific translational control of Cand2 by mTORC1 regulates adverse cardiac remodelingSemantic proximity Read

Cardiomyocyte-enriched protein CIP protects against pathophysiological stresses and regulates cardiac homeostasisSemantic proximity Read

Mitigation of Stress-induced Structural Remodeling and Functional Deficiency in iPSC-CMs with PLN R9C Mutation by Promoting AutophagySemantic proximity Read

CREG1 promotes autophagy and protects the heart against nutritional stress-induced injury and age-associated hypertrophy, fibrosis and diastolic dysfunctionSemantic proximity Read

SRPK3 regulates back-splicing of <i>pre-MYOCD</i> through Phosphorylating SRSF10 to modulate cardiac hypertrophySemantic proximity Read

skNAC is a Key Driver of Cardiomyocyte Integrity Against Pathological Cardiac Hypertrophy and Heart FailureSemantic proximity Read

LZTR1 polymerization provokes cardiac pathology in recessive Noonan syndromeSemantic proximity Read

Unmasking Supervillin <i>: SVIL</i> haploinsufficiency causes hypertrophic cardiomyopathy by impairing mechanotransduction and cellular energeticsSemantic proximity Read

SARS-CoV-2 Infects Human Pluripotent Stem Cell-Derived Cardiomyocytes, Impairing Electrical and Mechanical FunctionSemantic proximity Read

FGF12 Modulates Cardiomyocyte Hypertrophy by Inhibiting GATA4-ERK1/2 Phosphorylation Through Altered Intracellular LocalizationSemantic proximity Read

Unfolded Protein Response as a Compensatory Mechanism and Potential Therapeutic Target in PLN R14del Cardiomyopathy.Semantic proximity Read

Promoting Autophagy Mitigates Stress-Induced Remodeling in Patient iPSC-CMs with the Phospholamban R9C Mutation.Semantic proximity Read