Article

Engineered CXCR3-A expression enhances the trafficking and efficacy of intracerebroventricularly delivered B7-H3-targeting CAR T cells against diffuse intrinsic pontine glioma

2025-04-01

Abstract excerpt

<title>Abstract</title> <p>Diffuse intrinsic pontine glioma (DIPG) is a fatal brainstem tumor desperately in need of better treatments. CAR T cell therapies for DIPG have demonstrated clinical tolerability and bioactivity, but not universal benefit. A major obstacle is insufficient CAR T cell trafficking to the tumor. As our clinical trials have demonstrated locoregional elevation of CXCL10, a ligand of the chemo...

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Literature Corpus work: e694dc40-ad7c-5f3f-83b6-68c0b949cd12
DOI: 10.21203/rs.3.rs-6272325/v1

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