Novel and shared neoantigen derived from histone 3 variant H3.3K27M mutation for glioma T cell therapy.

doi:10.1084/jem.20171046

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Article

Novel and shared neoantigen derived from histone 3 variant H3.3K27M mutation for glioma T cell therapy.

The Journal of experimental medicine - 2 Jan 2018

Chheda Zinal S, Kohanbash Gary, Okada Kaori, Jahan Naznin, Sidney John, Pecoraro Matteo, Yang Xinbo, Carrera Diego A, Downey Kira M, Shrivastav Shruti, Liu Shuming, Lin Yi, Lagisetti Chetana, Chuntova Pavlina, Watchmaker Payal B, Mueller Sabine, Pollack Ian F, Rajalingam Raja, Carcaboso Angel M, Mann Matthias, Sette Alessandro, Garcia K Christopher, Hou Yafei, Okada Hideho

Abstract excerpt

The median overall survival for children with diffuse intrinsic pontine glioma (DIPG) is less than one year. The majority of diffuse midline gliomas, including more than 70% of DIPGs, harbor an amino acid substitution from lysine (K) to methionine (M) at position 27 of histone 3 variant 3 (H3.3). From a CD8+ T cell clone established by stimulation of HLA-A2+ CD8+ T cells with synthetic peptide encompassing the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29203539
DOI: 10.1084/jem.20171046
PMCID: PMC5748856

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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