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Article

Intranasal Oncolytic Virotherapy with CXCR4-Enhanced Stem Cells Extends Survival in Mouse Model of Glioma.

Stem cell reports - 13 Sept 2016

Dey Mahua, Yu Dou, Kanojia Deepak, Li Gina, Sukhanova Madina, Spencer Drew A, Pituch Katatzyna C, Zhang Lingjiao, Han Yu, Ahmed Atique U, Aboody Karen S, Lesniak Maciej S, Balyasnikova Irina V

Abstract excerpt

The challenges to effective drug delivery to brain tumors are twofold: (1) there is a lack of non-invasive methods of local delivery and (2) the blood-brain barrier limits systemic delivery. Intranasal delivery of therapeutics to the brain overcomes both challenges. In mouse model of malignant glioma, we observed that a small fraction of intranasally delivered neural stem cells (NSCs) can migrate to the brain...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27594591
DOI: 10.1016/j.stemcr.2016.07.024
PMCID: PMC5032402

Genes

CXCR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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