Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Developing H3K27M mutant selective radiosensitization strategies in diffuse intrinsic pontine glioma.

Neoplasia (New York, N.Y.) - 1 Mar 2023

Parsels Leslie A, Wahl Daniel R, Koschmann Carl, Morgan Meredith A, Zhang Qiang

Abstract excerpt

Diffuse intrinsic pontine glioma (DIPG) is a rare but highly lethal pediatric and adolescent tumor located in the pons of the brainstem. DIPGs harbor unique and specific pathological and molecular alterations, such as the hallmark lysine 27-to-methionine (H3K27M) mutation in histone H3, which lead to global changes in the epigenetic landscape and drive tumorigenesis. While fractionated radiotherapy, the current...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adolescent
Share to Brain Stem Neoplasms
Share to Child

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glioma

Share to Histones

Share to Mutation

Share to Neoplasm Recurrence, Local

Source

Open in PubMed Open full text

Identifiers

PMID: 36724689
DOI: 10.1016/j.neo.2023.100881
PMCID: PMC9918797

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Developing H3K27M mutant selective radiosensitization strategies in diffuse intrinsic pontine glioma.PMID 36724689Read ↗

The Molecular, Neurological, and Clinical Features of Diffuse Intrinsic Pontine GliomaSemantic proximity Read ↗

Diffuse intrinsic pontine glioma: current insights and future directionsSemantic proximity Read ↗

Epigenetic Targeted Therapy for Diffuse Intrinsic Pontine GliomaSemantic proximity Read ↗

Diffuse Intrinsic Pontine Glioma : Clinical Features, Molecular Genetics, and Novel Targeted TherapeuticsSemantic proximity Read ↗

Emerging Advances in Combinatorial Treatments of Epigenetically Altered Pediatric High-Grade H3K27M GliomasSemantic proximity Read ↗

H3 K27M-altered glioma and diffuse intrinsic pontine glioma: Semi-systematic review of treatment landscape and future directions.Semantic proximity Read ↗

Future Clinical Trials in DIPG: Bringing Epigenetics to the ClinicSemantic proximity Read ↗

Combined Targeting of Mutant p53 and Jumonji Family Histone Demethylase Augments Therapeutic Efficacy of Radiation in H3K27M DIPGSemantic proximity Read ↗

Children are not just little adults: recent advances in understanding of diffuse intrinsic pontine glioma biology.Semantic proximity Read ↗

Efficacy of chemoradiotherapy in pediatric H3K27M-mutant diffuse intrinsic pontine glioma: a study based on single-center and SEER data.Semantic proximity Read ↗

Combined Targeting of Mutant p53 and Jumonji Family Histone Demethylase Augments Therapeutic Efficacy of Radiation in H3K27M DIPGSemantic proximity Read ↗

Epigenetic-Targeted Treatments for H3K27M-Mutant Midline Gliomas.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.