Therapeutic Efficacy of Immune Stimulatory Thymidine Kinase and fms-like Tyrosine Kinase 3 Ligand (TK/Flt3L) Gene Therapy in a Mouse Model of High-Grade Brainstem Glioma.

doi:10.1158/1078-0432.CCR-19-3714

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Therapeutic Efficacy of Immune Stimulatory Thymidine Kinase and fms-like Tyrosine Kinase 3 Ligand (TK/Flt3L) Gene Therapy in a Mouse Model of High-Grade Brainstem Glioma.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Aug 2020

Mendez Flor, Kadiyala Padma, Nunez Felipe J, Carney Stephen, Nunez Fernando M, Gauss Jessica C, Ravindran Ramya, Pawar Sheeba, Edwards Marta, Garcia-Fabiani Maria Belen, Haase Santiago, Lowenstein Pedro R, Castro Maria G

Abstract excerpt

PURPOSE: Diffuse intrinsic pontine glioma (DIPG) bears a dismal prognosis. A genetically engineered brainstem glioma model harboring the recurrent DIPG mutation, Activin A receptor type I (ACVR1)-G328V (mACVR1), was developed for testing an immune-stimulatory gene therapy. EXPERIMENTAL DESIGN: We utilized the Sleeping Beauty transposase system to generate an endogenous mouse model of mACVR1 brainstem glioma....

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PMID: 32332014
DOI: 10.1158/1078-0432.CCR-19-3714
PMCID: PMC7415674

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