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Preclinical efficacy of combinatorial B7-H3 CAR T cells and ONC206 against diffuse intrinsic pontine glioma

2025-09-04

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Diffuse intrinsic pontine glioma (DIPG) is a fatal pediatric brain tumor affecting over 300 children annually in the United States. Chimeric antigen receptor (CAR) T cells are a targeted immune effector cell therapy with substantial clinical benefit against hematologic cancers. Against CNS tumors, CAR T cells targeting B7-H3, a protein highly expressed on DIPG, have rapidly...

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Literature Corpus work
4fed68d2-9f14-5261-9144-3f26224c0cab
DOI
10.1101/2025.09.01.673023
Open publication

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