Article
Characterization of the immune microenvironment of diffuse intrinsic pontine glioma: implications for development of immunotherapy.
Neuro-oncology - 1 Jan 2019
Lieberman Nicole A P, DeGolier Kole, Kovar Heather M, Davis Amira, Hoglund Virginia, Stevens Jeffrey, Winter Conrad, Deutsch Gail, Furlan Scott N, Vitanza Nicholas A, Leary Sarah E S, Crane Courtney A
Abstract excerpt
Background: Diffuse intrinsic pontine glioma (DIPG) is a uniformly fatal CNS tumor diagnosed in 300 American children per year. Radiation is the only effective treatment and extends overall survival to a median of 11 months. Due to its location in the brainstem, DIPG cannot be surgically resected. Immunotherapy has the ability to target tumor cells specifically; however, little is known about the tumor...
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