Article

Articular cartilage corefucosylation regulates tissue resilience in osteoarthritis

2023-09-29

Abstract excerpt

This study aimed to investigate the glycan structural changes that occur before histological degeneration in osteoarthritis (OA) and to determine the mechanism by which these glycan conformational changes affect cartilage degeneration. An OA model was established in rabbits using mannosidase injection, which reduced high-mannose type N-glycans and led to cartilage degeneration. Further analysis of glycome in human...

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Literature Corpus work: e684c9b0-c437-5afd-aabe-4c1b812766c0
DOI: 10.1101/2023.09.28.560052

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