Article
Loss of α2-6 sialylation promotes the transformation of synovial fibroblasts into a pro-inflammatory phenotype in arthritis.
Nature communications - 20 Apr 2021
Wang Yilin, Khan Aneesah, Antonopoulos Aristotelis, Bouché Laura, Buckley Christopher D, Filer Andrew, Raza Karim, Li Kun-Ping, Tolusso Barbara, Gremese Elisa, Kurowska-Stolarska Mariola, Alivernini Stefano, Dell Anne, Haslam Stuart M, Pineda Miguel A
Abstract excerpt
In healthy joints, synovial fibroblasts (SFs) provide the microenvironment required to mediate homeostasis, but these cells adopt a pathological function in rheumatoid arthritis (RA). Carbohydrates (glycans) on cell surfaces are fundamental regulators of the interactions between stromal and immune cells, but little is known about the role of the SF glycome in joint inflammation. Here we study stromal guided...
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