Article

Mucin-type <i>O</i> -glycans regulate proteoglycan stability and chondrocyte maturation

2025-12-13

Abstract excerpt

O -glycosylation is a ubiquitous post-translational modification essential for protein stability, cell signaling, and tissue organization, yet how distinct O -glycan subclasses coordinate tissue development remains unclear. Here, we identify functional crosstalk between extended mucin-type O -glycans and heparan sulfate proteoglycans (HSPGs). Genetic ablation of β-1,3-galactosyltransferase 1 (C1GALT1) or its cha...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 4124bb16-645b-582b-b81f-7255b115f7e5
DOI: 10.64898/2025.12.11.693745

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Mucin-type <i>O</i> -glycans regulate proteoglycan stability and chondrocyte maturationDOI 10.64898/2025.12.11.693745Read

Cosmc-dependent mucin-type O-linked glycosylation is essential for podocyte function.Semantic proximity Read

N‐glycoproteomics reveals distinct glycosylation alterations in NGLY1 ‐deficient patient‐derived dermal fibroblastsSemantic proximity Read

Global view of domain-specific O-linked mannose glycosylation in glycoengineered cellsSemantic proximity Read

Global mapping of GalNAc-T isoform-specificities and O-glycosylation site-occupancy in a tissue-forming human cell lineSemantic proximity Read

O-GalNAc glycans enrich in white matter tracts and regulate nodes of RanvierSemantic proximity Read

The cellular microenvironment and cell adhesion: a role for O-glycosylation.Semantic proximity Read

Variability in proteoglycan biosynthetic genes reveals new facets of heparan sulfates diversity. A systematic review and analysisSemantic proximity Read

Glycosyltransferase POMGNT1 deficiency affects N-cadherin-mediated cell-cell adhesionSemantic proximity Read

CSGALNACT1-congenital disorder of glycosylation: A mild skeletal dysplasia with advanced bone age.Semantic proximity Read

Role of Glycosyltransferase 25 Domain 1 in Type I Collagen Glycosylation and Molecular Phenotypes.Semantic proximity Read

Abnormal cartilage development and altered N-glycosylation in Tmem165-deficient zebrafish mirrors the phenotypes associated with TMEM165-CDG.Semantic proximity Read

O-GlcNAcylation modulates expression and abundance of N-glycosylation machinery in an inherited glycosylation disorder.Semantic proximity Read