Article

Mechanisms and Regulatory Networks of Extracellular Matrix-Related Proteins in Cartilage Degeneration of Osteoarthritis

2025-10-30

Abstract excerpt

Osteoarthritis (OA) is a chronic degenerative disease characterized predominantly by cartilage degradation, wherein extracellular matrix (ECM) proteins play pivotal roles in its pathogenesis. Proteins such as Asporin (ASPN), Cartilage Intermediate Layer Protein (CILP), Chondroadherin (CHAD), Fibulin-3 (EFEMP1), Pannexin 3 (PANX3), and C-terminal cross-linking telopeptide of type II collagen (CTX-II) exhibit aberra...

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Literature Corpus work: 197ebe24-dccd-54f8-af86-a2ec5593cee4
DOI: 10.20944/preprints202510.2364.v1

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