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Article

Targeting Fascin1 maintains chondrocytes phenotype and attenuates osteoarthritis development.

Bone research - 4 Sept 2024

Yang Panpan, Xiao Yun, Chen Liangyu, Yang Chengliang, Cheng Qinwei, Li Honghao, Chen Dalin, Wu Junfeng, Liao Zhengquan, Yang Changsheng, Wang Chong, Wang Hong, Huang Bin, Ke Ee, Bai Xiaochun, Li Kai

Abstract excerpt

Osteoarthritis (OA) is the most common form of arthritic disease, and phenotypic modification of chondrocytes is an important mechanism that contributes to the loss of cartilage homeostasis. This study identified that Fascin actin-bundling protein 1 (FSCN1) plays a pivotal role in regulating chondrocytes phenotype and maintaining cartilage homeostasis. Proteome-wide screening revealed markedly upregulated FSCN1...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39231936
DOI: 10.1038/s41413-024-00357-1
PMCID: PMC11374990

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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