Polo-like kinase 4 autodestructs by generating its Slimb-binding phosphodegron.

doi:10.1016/j.cub.2013.09.019

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Article

Polo-like kinase 4 autodestructs by generating its Slimb-binding phosphodegron.

Current biology : CB - 18 Nov 2013

Klebba Joseph E, Buster Daniel W, Nguyen Annie L, Swatkoski Stephen, Gucek Marjan, Rusan Nasser M, Rogers Gregory C

Abstract excerpt

Polo-like kinase 4 (Plk4) is a conserved master regulator of centriole assembly. Previously, we found that Drosophila Plk4 protein levels are actively suppressed during interphase. Degradation of interphase Plk4 prevents centriole overduplication and is mediated by the ubiquitin-ligase complex SCF(Slimb/βTrCP). Since Plk4 stability depends on its activity, we studied the consequences of inactivating Plk4 or...

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PMID: 24184097
DOI: 10.1016/j.cub.2013.09.019
PMCID: PMC3844517

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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