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Article

Polo-like kinase 4 controls centriole duplication but does not directly regulate cytokinesis.

Molecular biology of the cell - 1 May 2012

Holland Andrew J, Fachinetti Daniele, Da Cruz Sandrine, Zhu Quan, Vitre Benjamin, Lince-Faria Mariana, Chen Denaly, Parish Nicole, Verma Inder M, Bettencourt-Dias Monica, Cleveland Don W

Abstract excerpt

Centrioles organize the centrosome, and accurate control of their number is critical for the maintenance of genomic integrity. Centrioles duplicate once per cell cycle, and duplication is coordinated by Polo-like kinase 4 (Plk4). We previously demonstrated that Plk4 accumulation is autoregulated by its own kinase activity. However, loss of heterozygosity of Plk4 in mouse embryonic fibroblasts has been proposed to...

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Identifiers

PMID: 22456511
DOI: 10.1091/mbc.E11-12-1043
PMCID: PMC3350549

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Polo-like kinase 4 controls centriole duplication but does not directly regulate cytokinesis.PMID 22456511Read ↗

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