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Development, Structure, and Mechanism of Synthetic Antibodies that Target Claudin and <i>Clostridium perfringens</i> Enterotoxin Complexes

2022-01-02

Abstract excerpt

<h4>ABSTRACT</h4> Strains of the Gram-positive bacterium Clostridium perfringens produce a two-domain enterotoxin (CpE) that afflict millions of humans and domesticated animals annually by causing prevalent gastrointestinal illnesses. CpE’s C-terminal domain (cCpE) binds cell surface receptors then its N-terminal domain restructures to form a membrane-penetrating β -barrel pore, which is toxic to epithelial cel...

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Literature Corpus work
e6565ae4-d901-5e5c-820d-9c3f165a3882
DOI
10.1101/2022.01.01.474715
Open publication

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Development, Structure, and Mechanism of Synthetic Antibodies that Target Claudin and <i>Clostridium perfringens</i> Enterotoxin ComplexesDOI 10.1101/2022.01.01.474715
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