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Article

Structural basis for disruption of claudin assembly in tight junctions by an enterotoxin.

Scientific reports - 20 Sept 2016

Shinoda Takehiro, Shinya Naoko, Ito Kaori, Ohsawa Noboru, Terada Takaho, Hirata Kunio, Kawano Yoshiaki, Yamamoto Masaki, Kimura-Someya Tomomi, Yokoyama Shigeyuki, Shirouzu Mikako

Abstract excerpt

The food-poisoning bacterium Clostridium perfringens produces an enterotoxin (~35 kDa) that specifically targets human claudin-4, among the 26 human claudin proteins, and causes diarrhea by fluid accumulation in the intestinal cavity. The C-terminal domain of the Clostridium perfringens enterotoxin (C-CPE, ~15 kDa) binds tightly to claudin-4, and disrupts the intestinal tight junction barriers. In this study, we...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27647526
DOI: 10.1038/srep33632
PMCID: PMC5028891

Genes

CPE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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