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Article

Directed structural modification of Clostridium perfringens enterotoxin to enhance binding to claudin-5.

Cellular and molecular life sciences : CMLS - 1 Apr 2015

Protze Jonas, Eichner Miriam, Piontek Anna, Dinter Stefan, Rossa Jan, Blecharz Kinga Grażyna, Vajkoczy Peter, Piontek Joerg, Krause Gerd

Abstract excerpt

Clostridium perfringens enterotoxin (CPE) binds to distinct claudins (Clds), which regulate paracellular barrier functions in endo- and epithelia. The C-terminal domain (cCPE) has the potential for selective claudin modulation, since it only binds to a subset of claudins, e.g., Cld3 and Cld4 (cCPE receptors). Cld5 (non-CPE receptor) is a main constituent in tight junctions (TJ) of the blood-brain barrier. We...

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Identifiers

PMID: 25342221
DOI: 10.1007/s00018-014-1761-6
PMCID: PMC11113963

Genes

CPE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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