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Selection and characterization of ultrahigh potency designed ankyrin repeat protein inhibitors of C. difficile toxin B

24 Jun 2019

Abstract excerpt

Clostridium difficile infection (CDI) is a major nosocomial disease associated with significant morbidity and mortality. The pathology of CDI stems primarily from the 2 C. difficile-secreted exotoxins-toxin A (TcdA) and toxin B (TcdB)-that disrupt the tight junctions between epithelial cells leading to the loss of colonic epithelial barrier function. Here, we report the engineering of a series of monomeric and...

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PMID: 31233493
DOI: 10.1371/journal.pbio.3000311

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