Article

C. perfringens enterotoxin-claudin pore complex: Models for structure, mechanism of pore assembly and cation permeability

2024-08-06

Abstract excerpt

The pore-forming Clostridium perfringens enterotoxin (CPE), a common cause of foodborne diseases, facilitates Ca 2+ influx in enterocytes, leading to cell damage. Upon binding to certain claudins (e.g. claudin-4), CPE forms oligomeric pores in the cell membrane. While the CPE-claudin interaction mechanism is well known, the structure and assembly of the pore complex remain elusive. Here, using AlphaFold2 complex...

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Literature Corpus work: 69160da9-efa9-5866-88e3-26e7349cd41c
DOI: 10.1101/2024.08.02.605804

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