Article

Oligomerization of the <i>Clostridioides difficile</i> Transferase B Component Proceeds through a Stepwise Mechanism

2025-05-06

Abstract excerpt

Clostridioides difficile is a gram-positive, pathogenic bacterium and is currently the leading cause of hospital-acquired, infectious diarrhea in the United States. During infection, C. difficile produces and secretes up to three toxins called Toxin A, Toxin B, and the C. difficile transferase (CDT). While Toxin A and Toxin B are thought to drive the pathology associated with the disease, strains that produce CD...

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Literature Corpus work: 4443fa3c-b5a4-5a01-ab6f-f969580e47f1
DOI: 10.1101/2025.05.06.652354

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