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Article

Structure of a C. perfringens enterotoxin mutant in complex with a modified Claudin-2 extracellular loop 2.

Journal of molecular biology - 9 Sept 2014

Yelland Tamas S, Naylor Claire E, Bagoban Tannya, Savva Christos G, Moss David S, McClane Bruce A, Blasig Ingolf E, Popoff M, Basak Ajit K

Abstract excerpt

CPE (Clostridium perfringens enterotoxin) is the major virulence determinant for C. perfringens type-A food poisoning, the second most common bacterial food-borne illness in the UK and USA. After binding to its receptors, which include particular human claudins, the toxin forms pores in the cell membrane. The mature pore apparently contains a hexamer of CPE, claudin and, possibly, occludin. The combination of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25020226
DOI: 10.1016/j.jmb.2014.07.001
PMCID: PMC10921947

Genes

CPE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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