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Article

Identification of a Claudin-4 Residue Important for Mediating the Host Cell Binding and Action of <i>Clostridium perfringens</i> Enterotoxin

3 Nov 2009

Abstract excerpt

The 24-member claudin protein family plays a key role in maintaining the normal structure and function of epithelial tight junctions. Previous studies with fibroblast transfectants and naturally sensitive Caco-2 cells have also implicated certain claudins (e.g., Claudin-4) as receptors for Clostridium perfringens enterotoxin (CPE). The present study first provided evidence that the second extracellular loop...

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PMID: 19884339
DOI: 10.1128/iai.00778-09

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Identification of a Claudin-4 Residue Important for Mediating the Host Cell Binding and Action of <i>Clostridium perfringens</i> EnterotoxinPMID 19884339Read ↗

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