Article

DDR1 regulates RUNX1-CBFβ to control breast stem cell differentiation

2024-02-23

Abstract excerpt

The human breast is complex and comprised of multi-lineage and multi-structural elements. Recent work has shown that epithelial stem and progenitor cells use the collagen receptor Discoidin Domain Receptor 1 (DDR1) for differentiation into both basal and luminal cell lineages, which together are necessary for both ductal and alveolar morphogenesis. We developed a next-generation single cell derived organoid model...

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Literature Corpus work: e64b8820-6332-51b4-ab94-b2ec6883b852
DOI: 10.1101/2024.02.21.581255

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