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RUNX1 and RUNX2 transcription factors function in opposing roles to regulate breast cancer stem cells

17 Mar 2020

Abstract excerpt

Abstract Breast cancer stem cells (BCSCs) are competent to initiate tumor formation and growth and refractory to conventional therapies. Consequently BCSCs are implicated in tumor recurrence. Many signaling cascades associated with BCSCs are critical for epithelial‐to‐mesenchymal transition (EMT). We developed a model system to mechanistically examine BCSCs in basal‐like breast cancer using MCF10AT1 FACS sorted...

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PMID: 32180230
DOI: 10.1002/jcp.29625

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