ID4 controls mammary stem cells and marks breast cancers with a stem cell-like phenotype.

doi:10.1038/ncomms7548

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Article

ID4 controls mammary stem cells and marks breast cancers with a stem cell-like phenotype.

Nature communications - 27 Mar 2015

Junankar Simon, Baker Laura A, Roden Daniel L, Nair Radhika, Elsworth Ben, Gallego-Ortega David, Lacaze Paul, Cazet Aurélie, Nikolic Iva, Teo Wee Siang, Yang Jessica, McFarland Andrea, Harvey Kate, Naylor Matthew J, Lakhani Sunil R, Simpson Peter T, Raghavendra Ashwini, Saunus Jodi, Madore Jason, Kaplan Warren, Ormandy Christopher, Millar Ewan K A, O'Toole Sandra, Yun Kyuson, Swarbrick Alexander

Abstract excerpt

Basal-like breast cancer (BLBC) is a heterogeneous disease with poor prognosis; however, its cellular origins and aetiology are poorly understood. In this study, we show that inhibitor of differentiation 4 (ID4) is a key regulator of mammary stem cell self-renewal and marks a subset of BLBC with a putative mammary basal cell of origin. Using an ID4GFP knock-in reporter mouse and single-cell transcriptomics, we...

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PMID: 25813983
DOI: 10.1038/ncomms7548

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

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