Article
The Action of Discoidin Domain Receptor 2 in Basal Tumor Cells and Stromal Cancer-Associated Fibroblasts Is Critical for Breast Cancer Metastasis.
Cell reports - 14 Jun 2016
Corsa Callie A S, Brenot Audrey, Grither Whitney R, Van Hove Samantha, Loza Andrew J, Zhang Kun, Ponik Suzanne M, Liu Yuming, DeNardo David G, Eliceiri Kevin W, Keely Patricia J, Longmore Gregory D
Abstract excerpt
High levels of collagen deposition in human and mouse breast tumors are associated with poor outcome due to increased local invasion and distant metastases. Using a genetic approach, we show that, in mice, the action of the fibrillar collagen receptor discoidin domain receptor 2 (DDR2) in both tumor and tumor-stromal cells is critical for breast cancer metastasis yet does not affect primary tumor growth. In tumor...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.