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Discoidin domain receptor 2 regulates aberrant mesenchymal lineage cell fate and matrix organization

21 Dec 2022

Abstract excerpt

Extracellular matrix (ECM) interactions regulate both the cell transcriptome and proteome, thereby determining cell fate. Traumatic heterotopic ossification (HO) is a disorder characterized by aberrant mesenchymal lineage (MLin) cell differentiation, forming bone within soft tissues of the musculoskeletal system following traumatic injury. Recent work has shown that HO is influenced by ECM-MLin cell receptor...

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PMID: 36542719
DOI: 10.1126/sciadv.abq6152

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