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Article

DDR1 regulates RUNX1-CBFβ to control breast stem cell differentiation.

Stem cell reports - 12 Aug 2025

Trepicchio Colin, Rauner Gat, Traugh Nicole, Wang Ruohong, Parrish Meadow, Fein Daniel E C, Mal Youssof, Gupta Piyush B, Monti Stefano, Kuperwasser Charlotte

Abstract excerpt

Understanding epithelial stem cell differentiation and morphogenesis during breast tissue development is essential, as disruption in these processes underlie breast cancer formation. We used a next-generation single-cell-derived organoid model to investigate how individual stem cells give rise to complex tissue. We show that discoidin domain receptor 1 (DDR1) inhibition traps cells in a bipotent state, blocking...

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Source

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Identifiers

PMID: 40614729
DOI: 10.1016/j.stemcr.2025.102576
PMCID: PMC12365826

Genes

DDR1
RUNX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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