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Combined Mek inhibition and <i>Pparg</i> activation Eradicates Muscle Invasive Bladder cancer in a Mouse Model of BBN-induced Carcinogenesis

2023-08-21

Abstract excerpt

Bladder cancers (BCs) can be divided into 2 major subgroups displaying distinct clinical behaviors and mutational profiles: basal/squamous (BASQ) tumors that tend to be muscle invasive, and luminal/papillary (LP) tumors that are exophytic and tend to be non-invasive. Pparg is a likely driver of LP BC and has been suggested to act as a tumor suppressor in BASQ tumors, where it is likely suppressed by MEK-dependent...

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Literature Corpus work
e63d0469-06b8-5b71-ab3c-c4e7da7d9ef8
DOI
10.1101/2023.08.19.553961
Open publication

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Combined Mek inhibition and <i>Pparg</i> activation Eradicates Muscle Invasive Bladder cancer in a Mouse Model of BBN-induced CarcinogenesisDOI 10.1101/2023.08.19.553961
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