Article
EGFR as a potential therapeutic target for a subset of muscle-invasive bladder cancers presenting a basal-like phenotype.
Science translational medicine - 9 Jul 2014
Rebouissou Sandra, Bernard-Pierrot Isabelle, de Reyniès Aurélien, Lepage May-Linda, Krucker Clémentine, Chapeaublanc Elodie, Hérault Aurélie, Kamoun Aurélie, Caillault Aurélie, Letouzé Eric, Elarouci Nabila, Neuzillet Yann, Denoux Yves, Molinié Vincent, Vordos Dimitri, Laplanche Agnès, Maillé Pascale, Soyeux Pascale, Ofualuka Karina, Reyal Fabien, Biton Anne, Sibony Mathilde, Paoletti Xavier, Southgate Jennifer, Benhamou Simone, Lebret Thierry, Allory Yves, Radvanyi François
Abstract excerpt
Muscle-invasive bladder carcinoma (MIBC) constitutes a heterogeneous group of tumors with a poor outcome. Molecular stratification of MIBC may identify clinically relevant tumor subgroups and help to provide effective targeted therapies. From seven series of large-scale transcriptomic data (383 tumors), we identified an MIBC subgroup accounting for 23.5% of MIBC, associated with shorter survival and displaying a...
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