Article
A Carcinogen-induced mouse model recapitulates the molecular alterations of human muscle invasive bladder cancer.
Oncogene - 1 Apr 2018
Fantini Damiano, Glaser Alexander P, Rimar Kalen J, Wang Yiduo, Schipma Matthew, Varghese Nobish, Rademaker Alfred, Behdad Amir, Yellapa Aparna, Yu Yanni, Sze Christie Ching-Lin, Wang Lu, Zhao Zibo, Crawford Susan E, Hu Deqing, Licht Jonathan D, Collings Clayton K, Bartom Elizabeth, Theodorescu Dan, Shilatifard Ali, Meeks Joshua J
Abstract excerpt
The N-butyl-N-(4-hydroxybutyl)-nitrosamine (BBN) mouse model is an attractive model system of muscle-invasive bladder cancer (MIBC) as it recapitulates the histology of human tumors in a background with intact immune system. However, it was unknown whether this carcinogen-induced model also mimicked human MIBC at the molecular and mutational level. In our study, we analyzed gene expression and mutational...
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