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Urothelium-specific expression of mutationally activated <i>Pik3ca</i> initiates early lesions of non-invasive bladder cancer

2023-05-24

Abstract excerpt

Despite the fact that ∼70% of bladder cancers are non-invasive and have high recurrence rates, early stage disease is understudied. The relative lack of models to validate the contribution of molecular drivers of bladder tumorigenesis is a significant issue. While mutations in PIK3CA are frequent in human bladder cancer, an in vivo model for understanding their contribution to bladder tumorigenesis is unavailabl...

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Literature Corpus work
92b950de-af2b-5f3e-a023-a544b81233bc
DOI
10.1101/2023.05.22.541489
Open publication

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Urothelium-specific expression of mutationally activated <i>Pik3ca</i> initiates early lesions of non-invasive bladder cancerDOI 10.1101/2023.05.22.541489
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