Article

Defining the microenvironment landscape of bladder cancer using highly multiplexed spatial genomic and proteomic analysis

2019-06-21

Abstract excerpt

Muscle-invasive bladder cancer (MIBC) is an aggressive disease with limited therapeutic options. PD-1 pathway targeting immunotherapies have been approved to treat advanced bladder cancer, but most patients exhibit primary resistance, suggesting that immune evasion mechanisms exist. The PPARγ pathway has been identified as a potential therapeutic target in MIBC that is associated with reduced CD8+ T-cell infiltrat...

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Literature Corpus work: 0b6e1365-de45-5a4e-93c6-e9f75d70930a
DOI: 10.1101/675926

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