Article
Identification of distinct basal and luminal subtypes of muscle-invasive bladder cancer with different sensitivities to frontline chemotherapy.
Cancer cell - 10 Feb 2014
Choi Woonyoung, Porten Sima, Kim Seungchan, Willis Daniel, Plimack Elizabeth R, Hoffman-Censits Jean, Roth Beat, Cheng Tiewei, Tran Mai, Lee I-Ling, Melquist Jonathan, Bondaruk Jolanta, Majewski Tadeusz, Zhang Shizhen, Pretzsch Shanna, Baggerly Keith, Siefker-Radtke Arlene, Czerniak Bogdan, Dinney Colin P N, McConkey David J
Abstract excerpt
Muscle-invasive bladder cancers (MIBCs) are biologically heterogeneous and have widely variable clinical outcomes and responses to conventional chemotherapy. We discovered three molecular subtypes of MIBC that resembled established molecular subtypes of breast cancer. Basal MIBCs shared biomarkers with basal breast cancers and were characterized by p63 activation, squamous differentiation, and more aggressive...
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