Article
Distribution and expression of Pen-2 in the central nervous system of APP/PS1 double transgenic mice.
Acta biochimica et biophysica Sinica - 1 Apr 2015
Chu Yanan, Peng Xuehua, Long Zhiming, Wang Kejian, Luo Shifang, Sharma Akhilesh, He Guiqiong
Abstract excerpt
The γ-secretase complex catalyzes the final cleavage step of amyloid β-protein precursor (APP) to generate amyloid β (Aβ) peptide, a pathogenic component of senile plaques in the brain of Alzheimer's disease (AD) patients. Recent studies have shown that presenilin enhancer-2 (Pen-2), presenilin (PS, including PS1 and PS2), nicastrin, and anterior pharynx-defective 1 are essential components of the γ-secretase....
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