Article
Increased expression of PS1 is sufficient to elevate the level and activity of γ-secretase in vivo.
PloS one - 1 Jan 2011
Li Tong, Li Yue-Ming, Ahn Kwangwook, Price Donald L, Sisodia Sangram S, Wong Philip C
Abstract excerpt
Increase in the generation and deposition of amyloid-β (Aβ) plays a central role in the development of Alzheimer's Disease (AD). Elevation of the activity of γ-secretase, a key enzyme required for the generation for Aβ, can thus be a potential risk factor in AD. However, it is not known whether γ-secretase can be upregulated in vivo. While in vitro studies showed that expression of all four components of...
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