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Article

Activation and intrinsic gamma-secretase activity of presenilin 1.

Proceedings of the National Academy of Sciences of the United States of America - 14 Dec 2010

Ahn Kwangwook, Shelton Christopher C, Tian Yuan, Zhang Xulun, Gilchrist M Lane, Sisodia Sangram S, Li Yue-Ming

Abstract excerpt

A complex composed of presenilin (PS), nicastrin, PEN-2, and APH-1 is absolutely required for γ-secretase activity in vivo. Evidence has emerged to suggest a role for PS as the catalytic subunit of γ-secretase, but it has not been established that PS is catalytically active in the absence of associated subunits. We now report that bacterially synthesized, recombinant PS (rPS) reconstituted into liposomes exhibits...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21115843
DOI: 10.1073/pnas.1013246107
PMCID: PMC3003001

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Activation and intrinsic gamma-secretase activity of presenilin 1.PMID 21115843Read ↗

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