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Individual and combined presenilin 1 and 2 knockouts reveal that both have highly overlapping functions in HEK293T cells

6 Jun 2019

Abstract excerpt

Presenilins 1 and 2 (PS1 and 2) are the catalytic subunits of γ-secretase, a multiprotein protease that cleaves amyloid protein precursor and other type I transmembrane proteins. Previous studies with mouse models or cells have indicated differences in PS1 and PS2 functions. We have recently reported that clinical γ-secretase inhibitors (GSIs), initially developed to manage Alzheimer's disease and now being...

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PMID: 31167792
DOI: 10.1074/jbc.ra119.008041

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